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08.04.2021 By Tedal

All four methods succeed in detecting over half the disordered residues in the targets, with a generally low rate of over-prediction. Two of the methods perform significantly better when the structure of a related protein is available. There is a trade-off between the fraction of disordered residues detected and the extent of over-prediction, and groups have adopted different compromises in this respect. Comparison of performance at the same over-prediction rates highlights the role of related structures in some methods rather than others, with different groups achieving the highest sensitivity for different target sets.

Over-all, the methods are clearly of considerable use in identifying potential disorder. National Center for Biotechnology Information, U. HomologyBLAST (Basic Local Alignment Search Tool)BLAST (Stand-alone)BLAST Link (BLink)Conserved Domain Database (CDD)Conserved Domain Search Service (CD Search)Genome ProtMapHomoloGeneProtein ClustersAll Homology Resources. ProteinsBioSystemsBLAST (Basic Local Alignment Search Tool)BLAST (Stand-alone)BLAST Link (BLink)Conserved Domain Database (CDD)Conserved Domain Search Service (CD Search)E-UtilitiesProSplignProtein ClustersProtein DatabaseReference Sequence (RefSeq)All Proteins Resources.

Sequence AnalysisBLAST (Basic Local Alignment Search Tool)BLAST (Stand-alone)BLAST Link (BLink)Conserved Domain Search Service (CD Search)Genome ProtMapGenome WorkbenchInfluenza VirusPrimer-BLASTProSplignSplignAll Sequence Analysis Resources. TaxonomyTaxonomyTaxonomy BrowserTaxonomy Common TreeAll Taxonomy Resources. VariationDatabase of Genomic Structural Variation (dbVar)Database of Genotypes and Phenotypes (dbGaP)Database of Single Nucleotide Polymorphisms (dbSNP)SNP Submission ToolAll Variation Resources.

Add to ClipboardAdd to CollectionsOrder articlesAdd to My BibliographyGenerate a file for use with external citation management software. Create File See comment in PubMed Commons belowProteins. Melamud E1, Moult J. Author information1Center for Advanced Research in Biotechnology, University of Maryland Biotechnology Institute, Rockville, Maryland 20850, USA.

AbstractThis paper reports an analysis of the accuracy of predictions of structural disorder received as part of the CASP5 experiment. PMID: 14579346 DOI: 10. Please review our privacy policy. NLM National Center for Biotechnology Information, U. Brands will also focus on programmatic targeting and cross media placements that work together to drive synergies and deliver ROI. After playing catch-up to evolve their approach to reach Millennials, marketers will move more quickly in 2017 to connect with Generation Z.

Gen Z is coming of age in a post-linear digital world. Knowledge about everything is at their fingertips and on demand whenever they want it. These shifts will help drive brand growth and increase the power of digital as a channel for brands to meaningfully connect with this audience.

Connectivity has a fundamental influence on how people consume media and make brand choices. It gives brands the opportunity to increase reach exponentially. Marketers need to better meet the personal expectations of their consumers across different touchpoints.

The consumer journey has changed dramatically in recent years.

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Different types of consumers take different paths to purchase, and each use the internet in their own way. Trends in Europe, for example show that consumers pass from social, to brand-owned, to offline touchpoints throughout the consumer journey. But in emerging markets there is a far greater preference to interact with brands on social at all stages.

These differences create big challenges for channel owners, forced to play multiple roles and juggle numerous requests. And when comparing traditional digital touchpoints with mobile touchpoints marketers are faced with a greater risk of delivering an inconsistent brand experience. Marketers should also be aware of younger consumers who have grown up in a connected world.It was a pleasure working with J.

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It was an absolute pleasure working with JP and Gus on our website. They were very responsive and helped us to both beat our tight deadline and make the site look great. They had all the capabilities we needed and were able to solve a number of different challenges facing the site. I definitely recommend using Web Designer Express.

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The Kings are hoping for a better outcome after their 101-95 loss to the Cleveland Cavaliers in their last matchup. Zach Randolph led Sacramento in scoring with 18 points on 8-for-20 shooting. The last time the Pelicans played, they defeated the Denver Nuggets, 123-114. The Pelicans had a free throw rate of 0. DeMarcus Cousins was the top scorer from either team with 40 points on 12-for-25 shooting.

The sweet-shooting offense of New Orleans will go head-to-head against the porous defense of Sacramento.

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The Pelicans currently rank fifth in effective field goal percentage (0. The Pelicans should have the edge on that end of the court. Sacramento heads into the game with records of 7-17 straight up (SU) and 10-11-3 against the spread (ATS). Meanwhile, New Orleans owns records of 13-12 SU and 14-11 ATS.

Vegas tends to place the total low when the Pelicans are involved, as 56. Both teams have had a player take their game to the next level over their last five games. This is the second game of the season between these two teams. In the first, Cousins scored a game-high 41 points and the Pelicans beat the Kings 114-106, covering as 1-point underdogs.

He also recorded 23 rebounds and six assists. The game finished with a total of 220 points, which was 16 points above the projected point total of 204 points.

New Orleans had a much better offensive rebounding percentage (25.

New Orleans ranks second in assists per game (26. The Pelicans rank 12th in three pointers attempted per game (30. Sacramento ranks third in points off turnovers allowed per game (15. The Kings rank 10th in steals per game (8.Make a plan to do something different during the times you would normally smoke - change your routine. Go for a walk or exercise - this is key to relieving stress.

Choose a quit method you think will work best for you - gum, patch, spray, class or book program. Save it or spend it on a treat. Take one day at a time and always keep trying.

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Live Well Take the next step. Using PCB Visualizer results into a WIN-WIN situation between our designer customer and Eurocircuits. We therefore have no doubt to continue our investment in this magnificent tool.

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We will be more than happy to help. We will evaluate the content and if it fits the scope of what we publish then we will take it on board and inform you of it. Eurocircuits TV has started to capture the production steps one by one. Check out our eC-calendarEurocircuits meets studentsSupporting student projects is a top priority for Eurocircuits as students are our tomorrows customers.

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Why not follow us on our social media, keeping up to date with all of our latest news. For many, the result of an EMC test comes as an unpleasant surprise. Large amounts of money and time are spent in re-designing the product, which causes heavy delays. In this article, the author will give some simple advice and examples of test methods useful for avoiding undesired emission. Current lead-free soldering temperatures can damage temperature sensitive components.

An easy way to solve this problem is to use a soldering alloy with a lower melting point that allows for lower soldering temperatures. Currently however these alloys have limitations in shock and vibration resistance. This Intelligent Power Switch brings a clever solution to this problem: Power-On the Pi by pressing a pushbutton and also properly Power-Off the Pi with another press on the same button.

In many cases however you do not need to go to the edge of technology. Production Eurocircuits TV has started to capture the production steps one by one.

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Although hundreds of American cities have also banned plastic bags, the majority have not. Start bringing reusable bags with you on every trip to the store. Use a reusable water bottle or a glass jar and fill it at the tap. Ditch zip-top bags and plastic wrap for packing up leftovers and use reusable glass containers instead.

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You can safely reheat them in the microwave too.We will definitely book again- the only negative is that the time went by too quickly. We have just arrived back from a most memorable and enjoyable trip which you organised for us. Right from the beginning of our email correspondence, we have been impressed by the quality, dedication and effort you have put into making our tour of Scotland enjoyable. Thank you for going beyond what I would normally expect.

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We're just on the train back from Edinburgh, and wanted to say a big thank you for all your help organising our trip. We had an amazing time travelling round Scotland, and all the organization couldn't have been better. Everything went so smoothly - all the information you provided was so detailed and really helped us make the most of our trip.

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We were very pleased with the decision to up-grade from 'Standard' to 'Superior' accomodation. The 'Commodore Class' on the Ferry was very welcome. The car was upgraded as well, fantastic. We loved staying at the Basecamp Trapper's hotel. The place was really interesting and the staff very nice.

We pass along a special thanks to Lise at the hotel for her exceptional customer service and friendly personality. We also enjoyed the trip to Isfjord Radio, our wonderful guide Harri, and the great meals they served. Our 2 hour maxibus trip around Longyearbyen the day we arrived was a good introduction to the area. We made 2 changes to the package tour itinerary, and they ended up being the best parts of the trip. The first was a hike to Trollsteinen, which we included in our itinerary from the beginning, and it was amazing (for those who love to hike).

The second was a change we made at the last minute. On our last day we were signed up for an ATV trip, but it would have been to basically the same place we had seen the first day on the maxibus trip. We heard about a 10-hour boat trip to Pyramiden and Nordenskjoldbreen and booked it the night before. We loved this trip, with all we learned and the opportunity to see more of Spitsbergen.Article by Leon Hosking A winning formula Anna Woodward has become an important member of the award-winning bet365.

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Also, the Redskins won in Seattle just a few weeks ago and, I mean, did you watch that game on Thursday night. Like us on Facebook: PhillyVoice Sports Matt Mullin googletag. All rights reserved Facebook Twitter Google Plus LinkedIn Instagram Pinterest googletag.

MORE ON THE EAGLESEagles sign WR Alshon Jeffery to four-year extensionEagles-Seahawks injury report, with analysisRounding up the experts' picks for Eagles-SeahawksSeahawks haven't been this big of a home dog since.

Mailbag: Vikings would win most tiebreakers with EaglesBut not everyone believes that the Birds will improve to 11-1 on Sunday night. Rams Preview: Week 2 betting lines, predictions, analysis, how to watch USA TODAY Sports Redskins vs. Chicago The Washington Redskins are coming off a Week 1 loss to the Eagles at home, and now have to make a cross country trip to Los Angeles to face former offensive coordinator Sean McVay and the Rams.

The Redskins spent the week answering questions about a number of issues, most very similar to what we saw during the preseason, which definitely worries some people. Here are some of the biggest storylines and predictions from CSN Redskins insiders JP Finlay and Rich Tandler for Sunday. RELATED: WEEK 1 NFL POWER RANKINGSRadio: Redskins Radio Network, ESPN 710 AM, 100. The game is set to begin 4:25 p. Will playing their former offensive coordinator Sean McVay give them an advantage.

How much will it impact them. What were the trends we saw. What does Jay Gruden want to see to give him more. Jay Gruden expects more. In their last four road games against the Rams, however, the Redskins are just 1-3 SU and ATS. The Rams are 1-6 SU in their last seven games at home. JP Finlay: The Redskins offense looked terrible in Week 1, and it started with QB Kirk Cousins.

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Want some good news. That hasn't happened for the Washington passer in consecutive games since October 2015. Expect Cousins and the 'Skins offense to rebound in LA. Even with the bad effort against the Eagles, the Redskins till had a chance for the win late in that game. The effort will be better, the team won't turn the ball over four times, and Washington wins.

Gruden outlined the key for the Redskins in a press conference this week when he emphasized the importance of getting to the quarterback on several occasions. They should be able to both get to Jared Goff and, unlike last week, bring him down.

Prediction: Redskins 21, Rams 14Pete Hailey: Traveling West can be tough, and it's not something you want to do when you're already 0-1 and have a game against the physical, talented Raiders next week. But the Coliseum isn't exactly a frightening environment, and the Rams defense won't be able to bully the Redskins' offense like they did to Scott Tolzien and the Colts. Both Washington's offense and defense know what's on the line here.

Prediction: Redskins 24, Rams 20 A look back at the week in hot takes on Kirk Cousins Matt Ioannidis out of his cast Gruden on how Perine has improved in 2017 Josh Norman among five players under pressure vs.